Home Print this page Email this page Users Online: 55
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2011  |  Volume : 19  |  Issue : 1  |  Page : 28-32

Modulation of the acute phase post burn hypermetabolic response with propranolol


Dept of Plastic Surgery and Burns, Victoria Hospital, Bangalore medical College & RI, Bangalore, India

Correspondence Address:
Smitha S Segu
Assistant Professor of Plastic Surgery & Burns Banglore Medical College and Research Institute, Res-417, 12th Cross, Sadashiv Nagar, Bangalore-560080
India
Smitha S Segu
Assistant Professor of Plastic Surgery & Burns Banglore Medical College and Research Institute, Res-417, 12th Cross, Sadashiv Nagar, Bangalore-560080
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Introduction Thermal injury is followed by a period of hypermetabolism that is directly proportional to the size of insult sustained. Modulating postburn hypermetabolism is of overwhelming importance in both the immediate care stage and the rehabilitative stage. Postburn hypermetabolism cannot be completely reversed but may be manipulated by nonpharmacologic and pharmacologic means. Propranolol reduces hypermetabolism postburn. Aim To determine the effect of propranolol on hypermetabolism during the acute phase postburn by easily assessible clinical and investigational parameters. Methods A prospective randomized control study was conducted at Victoria Hospital, Bangalore between August 201 0 to June 201 1.100 patients with burns 15- 40% total body surface area were enrolled into the study and randomized to receive standard burn care (controls, n = 50) or standard burn care plus propranolol for more than 3 weeks (propranolol, 0.5-1.5 mglkg per oral every 6 hours, n = 50). Clinical parameters were assessed daily including weight, pulse rate /heart rate, sleeping pulse rate /heart rate and mid-arm circumference. Laboratory parameters, analyzed at regular intervals, included serum albumin, CRP and wound culture and sensitivity .The effect on wound healing and wound infection were also evaluated. Statistical analysis was performed using Student's t test. Results Patients in the control group and the propranolol group were similar with respect to weight, percentage of total body-surface area burned, percentage of body-surface area with third-degree burns, and length of time from injury to metabolic study. Propranolol treatment reduced heart rates and sleeping pulse rate by 25%, significantly increased serum albumin, while it significantly decreased CRP and urinary nitrogen (P < 0.05). The incidence of infection throughout hospital course was significantly lower in the propranolol group. An increase in weight and improvement in wound healing in the test group were noted. Conclusion Following burns, propranolol attenuates infections, inflammatory markers and while improving wound healing. We suggest that propranolol is a safe, cheap and efficacious modulator of the postburn response.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1483    
    Printed59    
    Emailed0    
    PDF Downloaded201    
    Comments [Add]    

Recommend this journal