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ORIGINAL ARTICLE
Year : 2011  |  Volume : 19  |  Issue : 1  |  Page : 38-41

Single blinded prospective comparative study of Recombinant human epidermal growth factor (rhEGF) + silver sulfadiazine Vs silver sulfadiazine (SSD) alone in treatment of second degree thermal burns


Department of Plastic Surgery & Burns, Victoria Hospital, Bangalore Medical College & RI, Bangalore, India

Correspondence Address:
Smitha S Segu
Assistant Professor of Plastic Surgery & Burns Banglore Medical College and Research Institute, Res-417, 12th Cross, Sadashiv Nagar, Bangalore-560080
India
Smitha S Segu
Assistant Professor of Plastic Surgery & Burns Banglore Medical College and Research Institute, Res-417, 12th Cross, Sadashiv Nagar, Bangalore-560080
India
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Source of Support: None, Conflict of Interest: None


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Introduction: Persistent burn wound leads to infection, internal organ failure, and malnutrition adding to significant morbidity. Early healing is a key step to prevent complications. rhEGF enhances the cellular proliferation and differentiation, hence promotes (4,6,7) wound healing. Aim: To compare role of rhEGF + silver sulfadiazine and silver sulfadiazine alone in healing of second degree thermal burn wounds. Patients & Methods: We conducted a single blinded prospective comparative study at the burns ward, Victoria hospital, Bangalore from August 2010 to June 2011. 32 patients ranging from 1yr to 40 yrs with TBSA ≤ 25% with second degree thermal burns were included. Pregnancy, infected wounds; chemical, electric & old burns were excluded. Paired burn wound of the same degree in the same patient were selected. One burn site was treated topically with SSD and labeled (A). The other site was treated with combination of SSD + rhEGF and labeled (B). Dressing was changed every alternate day. Each time a sterilized transparent sheet was placed on the wound & its perimeter was traced using a permanent marker. This was then transferred onto a metric graph and the area was measured by counting the number of squares. Sequential photographs of both sites were taken and the progress of healing observed. Results: The healing time of burn wound was (12+/-2) days (superficial II degree) and (24 +/- 2) days (deep II degree) at site (B), & (16 +/- 2) days (superficial II degree) and (30 +/- 2) days (deep II degree) at site (A), showing a significant difference in the healing between the two sites (P < 0.05). Conclusion: The combination of rhEGF with SSD can enhance burn wound healing significantly in second degree thermal burns.


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