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Year : 2018  |  Volume : 26  |  Issue : 1  |  Page : 66-71

Can removal of epidermis delay rejection of cadaveric dermis-only allograft? A proof of concept study

1 Department of Surgery, Plastic Surgery Unit, NSCB Government Medical College, Jabalpur, Madhya Pradesh, India
2 Department of Surgery, NSCB Government Medical College, Jabalpur, Madhya Pradesh, India
3 Department of Pathology, NSCB Government Medical College, Jabalpur, Madhya Pradesh, India

Correspondence Address:
Prof. Pawan Agarwal
292/293, Napier Town, Jabalpur - 482 003, Madhya Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijb.ijb_14_18

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Background: Skin allograft, used as a biological dressing, is usually rejected after 2 weeks. Epidermis contains immunogenic cells and its removal reduces antigenicity of allograft and delays its rejection. Materials and Methods: This proof of concept observational study was conducted in 50 patients of deep burns and posttraumatic wounds to evaluate the biological response of cadaveric glycerol-preserved dermis-only allograft. The epidermis was removed surgically, and the endpoints of healing or graft rejection were compared with historical controls of full-thickness allografts. Results: Dermis-only allograft take was seen in 82% patients at 20 days; in 34% patients at 4 weeks and in 16% patients at 8 weeks. Conclusion: Surgical removal of epidermis from cadaver allograft reduces its antigenicity and enables its longer survival.

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