Home Print this page Email this page Users Online: 2
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2018  |  Volume : 26  |  Issue : 1  |  Page : 77-82

To evaluate the role of Vitamin C in reducing the resuscitation fluid volume requirement in burned patients

1 Department of Plastic Surgery, Dayanand Medical College, Ludhiana, Punjab, India
2 Intern, Maulana Azad Medical College, New Delhi, India
3 Department of Pharmacology, Dayanand Medical College, Ludhiana, Punjab, India

Correspondence Address:
Dr. Sanjeev Uppal
133 H, BRS Nagar, Ludhiana - 141 012, Punjab
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijb.ijb_21_17

Rights and Permissions

Introduction: Free radicals released after burn injury lead to vascular endothelial injury and contribute to capillary leakage which in turn leads to burn edema. Antioxidant therapy (Vitamin C), to scavenge these free radicals, is suggested to limit endothelial injury and hence limit capillary leakage which in turn leads to reduction in fluid requirement to resuscitate the burn patient. Materials and Methods: This was a prospective, randomized study of 30 burn patients with 20%–60% burns. Fifteen patients were taken in each group. Group A patients were treated with only RL and Group B were treated with RL and adjuvant Vitamin C infusion. Fluid requirement, urine output, fluid balance, body weight gain, Vitamin C, and malondialdehyde (MDA) levels were noted. The two groups were then compared. Results: Fluid requirement in Group A was 3.74 ± 0.57 ml/kg/% of burns and in Group B was 2.46 ± 0.54 ml/kg/% of burns. Urine output was 1.05 ± 0.28 ml/kg/h in Group A, and in Group B, it was 1.42 ± 0.39 ml/kg/h. Fluid retention and body weight gain were lower in Group B. MDA levels were significantly lower at 36 h in Group B. Conclusion: Vitamin C, when given as adjuvant therapy in burns, decreases fluid requirement and lowers the MDA levels showing antioxidant effect of Vitamin C.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded146    
    Comments [Add]    
    Cited by others 1    

Recommend this journal